Summary

This study from MD Anderson Cancer Center demonstrates the efficacy of the Magseed® marker for breast lymph node marking post Neoadjuvant Chemotherapy

Key points

• 17 different radiologists placed 50 Magseed® markers into clipped lymph nodes
• 100% placed first attempt, 88% within the node
• 10 surgeons removed the Magseed® marked node, with 100% retrieval rate
• Removal of clipped nodes can be accomplished safely and effectively with Magseed® marker localization.

Summary

This meta analysis found that Magseed is a non-inferior, reliable and effective radiation-free localisation alternative to WGL, widely accepted by physicians as it decouples radiology and surgery schedules.

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Key points

• Covered 16 Magseed® studies, featuring 1,559 patients
• Overall re-excision rate of 11.19%
• Successful localization rate of 99.86%

Summary

This study was the largest non-radioactive seed series in the world, demonstrating a highly successful Magseed® marker program implementation.

Key points

• 842 Magseed® markers placed in 673 patients by 9 radiologists and removed by 6 surgeons at 6 different locations
• 136 lymph node localizations included
• Overall re-excision rate of 15%
• 99.5% Magseed® marker retrieval rate

Summary

This prospective single center study from MD Anderson Cancer Center concludes that the Magseed® marker is safe and effective for localisation and excision of non-palpable breast lesions

Key points

• 124 seeds placed in 93 patients
• All Magseed® markers placed within 10mm of the target
• 100% Magseed® retrieval rate
• 91% Negative margin rate

Summary

This study from the Royal Marsden Hospital investigates patient and clinician satisfaction and clinical outcomes for Magseed® localization, demonstrating a clinician preference for Magseed® and a reduction in patient anxiety

Key points

• 124 Magseed® markers compared against 168 WGL cases
• Patients treated with Magseed® reported less anxiety than those treated with wires
• Clinicians reported greater ease of use with Magseed® compared to wires
• Re-excision rates were the same between groups but the excised Magseed® specimens were statistically significantly smaller

Summary

This multi-center concludes that the Magseed® marker is a reliable marker for breast tumors and pathological axillary node localization in breast cancer patients.

Key points

• Included 41 Magseed® markers placed in 39 patients at 3 different institutions
• 7 of the markers were placed in TAD procedures
• 100% Magseed® retrieval rate
• 14.7% re-excision rate

Summary

This study from Charité hospital in Berlin, Germany concludes that the Magseed® marker is superior to WGL for patient comfort and reduces operative time.

Key points

• Significantly lower pain levels were reported after Magseed® localization compared to wires, including no pain in movement or sleep
• Magseed® showed a reduced operative time (14 mins) compared to wires (17.5)
• Magseed® operative time expected to decrease with experience

Summary

This study investigated the feasibility and efficacy of Magseed®, concluding it to be simple to use and that it consents short lumpectomy time, whilst improving the care pathway and organization of both radiological and surgical teams

Key points

• 20 Magseed® markers placed across 19 patients
• Magseed reduced incision to tumor resection time to an average of 11 minutes
• Patients reported very low pain levels at Magseed insertion (2/10)

Summary

This study evaluates the early adoption of the Magseed® marker compared to hookwire lesion localisation

Key points

• 100% intraoperative success for identifying and retrieving Magseed® markers
• No statistically significant difference between the Magseed® marker and hookwire re-excision rate
• Study includes the surgeons first Magseed® marker cases
• The Magseed® marker allowed surgical approach and incision placement independent of the localisation process

Summary

This study shows that the Magseed® marker is a safe, easy technique with a short learning curve, with efficient use of clinical resources

Key points

• No Magseed® marker migration
• 14.8% re-excision rate overall, over 12 surgeons
• No re-excisions for invasive carcinoma required
• Clinicians found Magseed® marker quicker and easier than a wire
• All Magseed® markers localised, even in very large breasts

Summary

This study shows that Magseed® marker localization is a safe, nonradioactive way to accurately localize axillary lymph nodes preoperatively

Key points

• 35 patients received Magseed® marker node localization
• 100% surgical success with 97% Magseed® marker retrieval rate
• One Magseed® marker was misplaced in the OR, however no regulatory issue with magnetic technology

Summary

This study demonstrates accurate lesion localisation and SLN detection with the combined use of the Magseed® marker and Magtrace® lymphatic tracer

Key points

• No Magseed® marker migration was noted and low tumour resection volumes were documented (CRR - 1.49)
• Peritumoral injection of the Magtrace® lymphatic tracer was utilised and all SLNB’s were successful
• Clinicians reported the method was easier than hook-wire localisation
• Hospital scheduling was improved

Summary

This study demonstrates the combined use of the Magseed® marker and Magtrace® lymphatic tracer for lesion localisation and SLNB

Key points

• All lesions were successfully excised with tumour-free margins
• SLNB was successful in all patients
• The Magtrace® lymphatic tracer was injected subareolar pre or post operatively
• No interference between the Magseed® marker and Magtrace® lymphatic tracer signals was noted

Summary

This study shows that the Magseed® marker can be accurately placed, demonstrates no migration and is detectable in all sizes and depths of breast tissue

Key points

• The Magseed® marker was detectable in all breast sizes (maximum 2.6kg)
• There were no complication or safety issues
• No Magseed® marker migration was noted

Summary

This study – featuring 188 patients – shows that Magseed® marker localisation has the potential to replace conventional wire needle localisation

Key points

• 96.7% of Magseed® markers placed accurately first attempt
• 100% successful Magseed® marker retrieval rate
• No complications associated with the Magseed® marker

Summary

This study demonstrates the benefits of implementing a Magseed® marker program into a large hospital facility.

Key points

• The Magseed® marker allows for decoupling of the localisation and day of surgery
• The Magseed® marker bypasses regulatory disadvantages associated with radioactive seed localisation
• The Magseed® marker is 'indestructable', non-radioactive and poses no danger to clinical staff
• A reduction in OR delays was noted
• Great radiology flexibility was achieved

Summary

This study from UCSF shows that the Magseed® marker provides an effective means for preoperative localisation of non-palpable breast lesions

Key points

• The Magseed® marker was adopted as standard of care after a two week evaluation
• The first 4 months of Magseed® marker cases are reported on
• 100% placement and retrieval success
• Seed placement was extremely accurate
• Overall 12% re-excision rate